Your Outsourcing Partner for Protein Research and Production Services

To meet the needs of our clients, Exon BioSystems provides protein characterization of our expressed protein to insure the quality of recombinant protein.

Recombinant Protein Expression

Exon BioSystems is a protein contract research and production services company specializing in recombinant protein expression, protein purification, and protein characterization.

Antibody Engineering

Additional areas of expertise include assay development of G-protein coupled receptor, recombinant vaccine development and recombinant antibody production.

Biologics

Exon BioSystems is a protein contract research and production services company specializing in recombinant protein expression, protein purification, and protein characterization.

About

Protein Modification


Glycosylation is perhaps the most common and versatile post-translational modification of proteins. It is estimated that well over one-half of all mammalian proteins are glycosylated. The roles of protein glycans, whether N- or O-linked forms tend to vary. Glycan is required for the biological function of certain proteins, such as,

  • The Fc-effector function of immunoglobulin G (IgG).
  • The regulated clearance of the glycohormone lutropin (LH),
  • The targeting of lysosomal enzymes and,
  • Controlling the circulation lifetime of glycoprotein drugs.

Glycans can also serve as:

  • Recognition targets for their complementary binding proteins, the lectins.
  • Serving as sites of attachment by microbes and toxins, and often constitute the first contact point between pathogen and host.
  • Protecting proteins from proteolytic enzymes.
  • Promoting protein foldinginto proper tertiary and quaternary structure.
  • Modulating the biological activities of protein.

GlycosylationGlycosylation



Interestingly, N-glycosylation pathway of baculovirus infected insect cells differs from the pathway found in higher eukaryotes, as indicated by the fact that glycoproteins produced in the baculovirus system typically lack complex biantennary N-linked oligosaccharide side chains containing galactose and terminal sialic acid residues Jarvis DL and Finn EE, Nature Biotechnology 1996).

For authentic glycosylation modification, our mammalian expression systems provides your best choice.

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For more information please call _858-457-1920 or e-mail us at: info @ exonbio.com, or use our contact page: Contact