Antibody Affinity Maturation
Team up with PhD Antibodies (link) we provide antibody affinity maturation service for customers looking for antibodies with higher affinity and less off-target binding.
Technology:1. Systematic CDR mutantion. We employ a systematic but simple one-by-one mutagenesis of every residue of CDR to make multiple small libraries in paralell. That strategy significantly speed up the maturation procedure and this strategy was proved the most effective.
2. No-display technoloy. PhD antibodies (link) employ a Phage technology without display to screening mutant libraries from CDR mutagenesis. That technology is faster and more efficent comparing to conventional phage display technology.