Antibodies developed from immunized animals often be immunogenic to human body, leading to shorter half-lives and immune responses in vivo. Antibody humanization involves the modification of animal monoclonal antibodies to resemble human IgG so that the human immune system recognize the humanized antibody as a self component. The new antibodies retain epitope specificity but contain human segments to reduce HAMA
We humanize animal antibodies (murine, rabbit, llama or chicken antibodies) by chimera, CDR-graft and epitope guided screening.
- • Retain epitope binding specificity.
- • Retain or enhance the affinity.
- • Increase in vivo half-life of antibody therapies.