Your Outsourcing Partner for Protein Research and Production Services

 Exon BioSystems is a protein contract research and production services company specializing in recombinant protein expression, protein purification, and protein characterization.

Additional areas of expertise include assay development of G-protein coupled receptor, recombinant vaccine development and recombinant antibody production.

At the post-genomic era, the enormous demand of recombinant proteins for high throughput screening and structural based drug discovery (SBDD) requires premium quality recombinant proteins. Whether you are focused on preclinical discovery, small and large-scale production of identified targets, or characterization of difficult to express fusion proteins, we can help you find the right solution to your challenge in a cost effective manner.

Molecular Biology Services

In the absence of the gene of interest in hands, Exon BioSystems offers to our customers the ability to synthesize the actual gene. Different organisms have different codon usage preferences, thus we also. perform codon optimization for high efficient expression in E. coli, insect cells, and mammalian host systems

We also provide cloning and subcloning services to free your energy and time for your downstream research. Our subcloning service is highly flexible to any specific project requirements.

If your research needs some modifications of a gene, such as truncation, deletion, insertion, point mutation, domain swapping or gene fusion, Exon BioSystems provides the expertise such as Site-directed Mutagenesis and conventional molecular techniques to help you reach your goal.

Using multiple expression systems, including bacterial, insect and mammalian expression systems, ExonBio has the capability to produce “hard to express proteins”, such as membrane proteins, at milligram level. Whether you’re focused on lead discovery, assay development, vaccine production, high throughput screening, or characterization of interesting gene products, We can find a solution for you.

Protein Purification

Obtaining enough protein in high purity is often the challenge of a research project that requires high quality protein for structural biology and functional validation. For animal studies, the formulation must be devoid of any contaminants including endotoxin and virus. It is imperative, therefore, that therapeutic proteins, recombinant vaccines and diagnostic proteins be purified to the highest level possible.

A full range of purification methods, allowing you to choose the ideal level of purity of the material for your intended application is available for both small and large amounts of protein. 

Combining our skills developed over the past twenty years in protein biochemistry, we deliver efficient and cost effective solutions in protein purification.

Protein Characterization

To meet the need of our clients, Exon Biosystems provides protein characterization of the expressed protein for further down stream applications. Routinely SDS-PAGE and Western blotting will be carried out to asess the purity of the expressed protein. In addition, N-terminal sequencing and mass spectrometry (MS) are available. As an extended part of the protein characterization, Exon BIoSystems can provide a functional assay of the recombinant protein.